van der Laan L J W, de Ruiter P E, van Gils I M, Fieten H, Spee B, Pan Q, Rothuizen J, Penning L C
Department of Surgery, Erasmus MC-University Medical Center, Rotterdam, The Netherlands.
J Viral Hepat. 2014 Dec;21(12):894-6. doi: 10.1111/jvh.12268. Epub 2014 Jun 5.
Liver diseases are highly prevalent in the general dog population, though the etiology is often unknown. Recently a homolog of human hepatitis C virus was discovered in dogs with respiratory infections. Although this canine hepacivirus (CHV) was detectable in some liver samples, a clear link with liver disease has not been established. A recent study by Bexfield et al. showed that in a large cohort of dogs from the UK with idiopathic hepatitis, no evidence can be found for exposure to, or carrier state of CHV both in liver and in serum. The authors however state that 'the absence of CHV infection on dogs from the UK might not represent the global ecology of the virus'. We investigated CHV-infection in 267 liver biopsies from 120 dogs idiopathic hepatitis and 135 control animals, in a population from the Netherlands. Using a highly sensitive PCR assay for CHV-NS3, no CHV was detected in all 267 liver samples. Our data show that the lack of association between canine hepacivirus and chronic liver disease in dogs is not limited to the UK, but is also found in an independent cohort from the European continent.
肝脏疾病在普通犬类群体中非常普遍，尽管其病因通常不明。最近在患有呼吸道感染的犬类中发现了一种人类丙型肝炎病毒的同源物。虽然这种犬肝病毒（CHV）在一些肝脏样本中可检测到，但尚未确定其与肝脏疾病的明确联系。贝克斯菲尔德等人最近的一项研究表明，在一大群来自英国的患有特发性肝炎的犬类中，在肝脏和血清中均未发现接触CHV或CHV携带状态的证据。然而，作者指出，“英国犬类中未感染CHV可能并不代表该病毒的全球生态情况”。我们在来自荷兰的一群犬类中，对120只患有特发性肝炎的犬类和135只对照动物的267份肝脏活检样本进行了CHV感染情况调查。使用针对CHV-NS3的高灵敏度PCR检测方法，在所有267份肝脏样本中均未检测到CHV。我们的数据表明，犬肝病毒与犬类慢性肝病之间缺乏关联的情况不仅限于英国，在来自欧洲大陆的一个独立队列中也有发现。
