Li Chao, Liu Da-ren, Ye Long-yun, Huang Ling-na, Jaiswal Sanjay, Li Xiao-wen, Wang Hou-hong, Chen Li
Department of Surgery, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310021, China.
J Zhejiang Univ Sci B. 2014 Jun;15(6):582-9. doi: 10.1631/jzus.B1300258.
Numerous studies examining the relationship between human epidermal growth factor receptor 2 (HER-2) overexpression and survival in patients with colorectal cancer (CRC) have yielded controversial results. We therefore performed a meta-analysis more precisely to estimate its prognostic value.
Published studies investigating the effect of HER-2 overexpression on CRC survival were identified; the hazard ratios (HRs) and their corresponding 95% confidence intervals (95% CIs) were pooled in terms of disease-specific or overall survival.
Eleven studies were included in the meta-analysis. The pooled data showed that HER-2 overexpression was negatively related to CRC survival (HR=1.10, 95% CI: 0.77-1.44). Subgroup analyses regarding test method and study quality also demonstrated little association between HER-2 overexpression and CRC survival (HR=0.89, 95% CI: 0.50-1.29; HR=0.90, 95% CI: 0.43-1.37, respectively).
Regardless of several limitations, our study suggested that HER-2 overexpression probably had little impact on CRC survival.
众多研究探讨了人类表皮生长因子受体2（HER-2）过表达与结直肠癌（CRC）患者生存率之间的关系，但其结果存在争议。因此，我们进行了一项荟萃分析，以更精确地评估其预后价值。
检索已发表的研究，这些研究调查了HER-2过表达对CRC生存的影响；根据疾病特异性生存或总生存汇总风险比（HR）及其相应的95%置信区间（95%CI）。
荟萃分析纳入了11项研究。汇总数据显示，HER-2过表达与CRC生存呈负相关（HR=1.10，95%CI：0.77-1.44）。关于检测方法和研究质量的亚组分析也表明，HER-2过表达与CRC生存之间几乎没有关联（HR分别为0.89，95%CI：0.50-1.29；HR为0.90，95%CI：0.43-1.37）。
尽管存在一些局限性，但我们的研究表明，HER-2过表达可能对CRC生存影响不大。
