Moon Seung Hwan, Noh Tae Soo, Cho Young Seok, Hong Seon Pyo, Hyun Seung Hyup, Choi Joon Young, Kim Byung-Tae, Lee Kyung-Han
Department of Nuclear Medicine and Molecular imaging, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Department of Nuclear Medicine and Molecular imaging, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
Angiology. 2015 May;66(5):472-80. doi: 10.1177/0003319714537872. Epub 2014 Jun 5.
We assessed the association between nonalcoholic fatty liver disease (NAFLD) and carotid artery inflammation measured by (18)F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography. Participants were 755 consecutive otherwise healthy adult males who underwent a general health screening program. Carotid FDG uptake, represented as maximum target-to-background ratio, was increased with mild (n = 237; 1.61 ± 0.14; P = .033) and moderate NAFLD (n = 145; 1.63 ± 0.16; P = .005) compared with controls (n = 373; 1.58 ± 0.15). In patients aged >50 years, moderate NAFLD was the only independent risk factor for high carotid FDG uptake (odds ratio, 2.12; 95% confidence interval, 1.10-4.07; P = .001). Apparently healthy adult males with NAFLD have elevated carotid FDG uptake as well as increased carotid intima-media thickness, suggesting that they may be at an increased risk of having inflammatory atherosclerotic plaques in the carotid arteries.
我们评估了非酒精性脂肪性肝病（NAFLD）与通过（18）F-氟脱氧葡萄糖（FDG）正电子发射断层扫描/计算机断层扫描测量的颈动脉炎症之间的关联。参与者为755名连续接受一般健康筛查项目的健康成年男性。与对照组（n = 373；1.58±0.15）相比，轻度NAFLD（n = 237；1.61±0.14；P = 0.033）和中度NAFLD（n = 145；1.63±0.16；P = 0.005）患者的颈动脉FDG摄取（以最大靶本底比表示）增加。在年龄大于50岁的患者中，中度NAFLD是颈动脉FDG摄取高的唯一独立危险因素（比值比，2.12；95%置信区间，1.10 - 4.07；P = 0.001）。患有NAFLD的看似健康的成年男性颈动脉FDG摄取升高，颈动脉内膜中层厚度增加，这表明他们患颈动脉炎症性动脉粥样硬化斑块的风险可能增加。
