D'Onofrio David J, Abel David L
Control Systems Modeling and Simulation, General Dynamics Sterling Heights, MI, USA ; Department of Humanities and Science, Math Department, College of Humanities and Science, University of Phoenix Detroit, MI, USA.
Department of ProtoBioCybernetics/ProtoBioSemiotics, The Gene Emergence Project of The Origin of Life Science Foundation, Inc. Greenbelt, MD, USA.
Front Genet. 2014 May 20;5:140. doi: 10.3389/fgene.2014.00140. eCollection 2014.
The codon redundancy ("degeneracy") found in protein-coding regions of mRNA also prescribes Translational Pausing (TP). When coupled with the appropriate interpreters, multiple meanings and functions are programmed into the same sequence of configurable switch-settings. This additional layer of Ontological Prescriptive Information (PIo) purposely slows or speeds up the translation-decoding process within the ribosome. Variable translation rates help prescribe functional folding of the nascent protein. Redundancy of the codon to amino acid mapping, therefore, is anything but superfluous or degenerate. Redundancy programming allows for simultaneous dual prescriptions of TP and amino acid assignments without cross-talk. This allows both functions to be coincident and realizable. We will demonstrate that the TP schema is a bona fide rule-based code, conforming to logical code-like properties. Second, we will demonstrate that this TP code is programmed into the supposedly degenerate redundancy of the codon table. We will show that algorithmic processes play a dominant role in the realization of this multi-dimensional code.
mRNA蛋白质编码区中发现的密码子冗余（“简并性”）也规定了翻译暂停（TP）。当与适当的解读器结合时，多种含义和功能被编入相同的可配置开关设置序列中。这种额外的本体规定信息（PIo）层会有意地减缓或加速核糖体中的翻译解码过程。可变的翻译速率有助于规定新生蛋白质的功能性折叠。因此，密码子到氨基酸的映射冗余绝非多余或退化。冗余编程允许在不产生串扰的情况下同时对TP和氨基酸分配进行双重规定。这使得两种功能能够同时实现。我们将证明TP模式是一种真正的基于规则的代码，符合类似逻辑代码的属性。其次，我们将证明这种TP代码被编入了密码子表中所谓的简并冗余中。我们将表明算法过程在这种多维代码的实现中起主导作用。
