竞争性内源性 RNA 不能改变体内 microRNA 的功能。
Competitive endogenous RNAs cannot alter microRNA function in vivo.
机构信息
RNA Therapeutics Institute, Department of Biochemistry and Molecular Pharmacology, and Howard Hughes Medical Institute, University of Massachusetts Medical School, ASC4-2053, 368 Plantation Street, Worcester, MA 01605, USA.
出版信息
Mol Cell. 2014 Jun 5;54(5):711-3. doi: 10.1016/j.molcel.2014.05.023.
PMID:24905003
Abstract
In this issue of Molecular Cell, Denzler et al. (2014) report a quantitative study of microRNA function in adult mouse liver, suggesting that the natural abundance of miRNAs and their binding sites generally excludes the previously proposed regulation of miRNAs by competitive endogenous RNAs (ceRNAs).
摘要
在本期《分子细胞》中，Denzler 等人（2014）报告了一项关于成年小鼠肝脏中 microRNA 功能的定量研究，表明 microRNA 的自然丰度及其结合位点通常排除了先前提出的 microRNA 被竞争性内源 RNA（ceRNA）调控的观点。
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