Elujoba A A, Ajulo O O, Iweibo G O
Department of Pharmacognosy, Faculty of Pharmacy, Obafemi Awolowo University, Ile-Ife, Nigeria.
J Pharm Biomed Anal. 1989;7(12):1453-7. doi: 10.1016/0731-7085(89)80150-5.
The leaves of 10 Cassia species (Leguminosae), cultivated in Nigeria, were assayed spectrophotometrically for combined anthraquinone content and also pharmacologically for their laxative properties in male albino rats using official senna leaves (Cassia acutifolia Del.) as the reference standard. Leaves of C. podocarpa Guill, and Perr. and of senna had identical laxative potency. The results of both the chemical and the biological experiments suggested that C. alata L. and C. podocarpa are the most likely candidates for drug development in Nigeria. The use of a laxative index is proposed for the comparative study of Cassia (or any plant species) and its possible application to the quality control of these drugs is discussed.
对在尼日利亚种植的10种决明属（豆科）植物的叶子进行了分光光度法测定，以检测其蒽醌总含量，并以官方标准番泻叶（Cassia acutifolia Del.）为参比标准，在雄性白化大鼠身上对其通便特性进行了药理学研究。C. podocarpa Guill.和Perr.以及番泻叶的叶子具有相同的通便效力。化学实验和生物学实验的结果均表明，C. alata L.和C. podocarpa最有可能成为尼日利亚药物开发的候选植物。本文提出使用通便指数来对比研究决明属植物（或任何植物物种），并讨论了其在这些药物质量控制中的可能应用。
