Department of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University (A Central University), Lucknow, India.
Department of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University (A Central University), Lucknow, India.
Pharmacol Rep. 2014 Feb;66(1):165-8. doi: 10.1016/j.pharep.2013.06.011. Epub 2014 Feb 1.
The present study was undertaken to elucidate the effect of omeprazole and baclofen on experimental esophagitis in albino rats.
Groups of rats, fasted overnight received normal saline (3 ml/kg, ip; sham control) or toxic control (3 ml/kg, ip) or omeprazole (30 mg/kg, ip) or baclofen (20 mg/kg, ip) or their combinations, were subjected to the pylorus and forestomach ligation. Animals were sacrificed after 6 h and evaluated for the gastric pH, volume of gastric juices, total acidity, esophagitis index and free acidity. Esophageal tissues were further subjected to estimations of TBARS, GSH, catalase and SOD.
Treatment with omeprazole and baclofen significantly inhibited the gastric secretion, total acidity and esophagitis index. The treatment also helped to restore the altered level's oxidative stress parameters to normal.
The beneficial effect of omeprazole and baclofen against GERD could be conglomerately attributed to the antisectretory action of omeprazole and reduction in the tracheal lower esophageal sphincter release rate by baclofen.
本研究旨在阐明奥美拉唑和巴氯芬对白化大鼠实验性食管炎的影响。
禁食过夜的大鼠组接受生理盐水（3 ml/kg，ip；假对照）或毒性对照（3 ml/kg，ip）或奥美拉唑（30 mg/kg，ip）或巴氯芬（20 mg/kg，ip）或它们的组合，进行幽门和前胃结扎。6 小时后处死动物，评估胃 pH 值、胃液量、总酸度、食管炎指数和游离酸度。进一步对食管组织进行 TBARS、GSH、过氧化氢酶和 SOD 的测定。
奥美拉唑和巴氯芬治疗可显著抑制胃酸分泌、总酸度和食管炎指数。该治疗还有助于将改变的氧化应激参数恢复到正常水平。
奥美拉唑和巴氯芬对 GERD 的有益作用可能归因于奥美拉唑的抗分泌作用和巴氯芬降低气管下食管括约肌的释放率。
