泮托拉唑与阿瑞匹坦单一疗法及联合疗法对白化病大鼠胃食管反流病的影响。
Effect of monotherapy and combination therapy of pantoprazole and aprepitant in gastric esophageal reflux disease in albino rats.
作者信息
Shukla Kamleshwar, Raj Prince, Kumar Arun, Kumar Mukesh, Kaithwas Gaurav
机构信息
Department of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University, Vidya Vihar, Raebareli Road, Lucknow 226 025, India.
Department of Applied Animal Sciences, Babasaheb Bhimrao Ambedkar University, Vidya Vihar, Raebareli Road, Lucknow 226 025, India.
出版信息
ScientificWorldJournal. 2014 Mar 23;2014:183147. doi: 10.1155/2014/183147. eCollection 2014.
The present study was undertaken to elucidate the effect of pantoprazole and aprepitant on experimental esophagitis in albino rats. Groups of rats, fasted overnight, received normal saline (3 mL/kg, sham control) or toxic control (3 mL/kg) or pantoprazole (30 mg/kg) or aprepitant (10 mg/kg), or their combinations and were subjected to pylorus and forestomach ligation. Animals were sacrificed after 8 h and evaluated for the gastric pH, volume of gastric juices, total acidity, esophagitis index, and free acidity. Esophageal tissues were further subjected to estimations of TBARS, GSH, catalase, and SOD. Treatment with pantoprazole and aprepitant significantly inhibited the gastric secretion, total acidity, and esophagitis index. The treatment also helped to restore the altered levels oxidative stress parameters to normal.
本研究旨在阐明泮托拉唑和阿瑞匹坦对白化病大鼠实验性食管炎的影响。将大鼠分组，禁食过夜，分别给予生理盐水（3 mL/kg，假对照组）或毒性对照组（3 mL/kg）或泮托拉唑（30 mg/kg）或阿瑞匹坦（10 mg/kg），或它们的组合，然后进行幽门和前胃结扎。8小时后处死动物，评估胃pH值、胃液体积、总酸度、食管炎指数和游离酸度。食管组织进一步用于测定丙二醛（TBARS）、谷胱甘肽（GSH）、过氧化氢酶和超氧化物歧化酶（SOD）。泮托拉唑和阿瑞匹坦治疗显著抑制了胃液分泌、总酸度和食管炎指数。该治疗还有助于将氧化应激参数的改变水平恢复正常。
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