亚麻籽固定油对白化大鼠实验性食管炎的影响。

Effect of Linum usitatissimum (linseed/flaxseed) fixed oil on experimental esophagitis in albino rats.

作者信息

Renu N, Kaithwas G, Ramteke P W, Saraf S A

机构信息

Department of Pharmaceutical Sciences, Faculty of Health and Medical Sciences, SHIATS, Formerly Allahabad Agricultural Institute-Deemed to be University, Allahabad-211 007, Uttar Pradesh, India.

出版信息

Acta Gastroenterol Belg. 2012 Sep;75(3):331-5.

PMID:23082704

Abstract

INTRODUCTION

The present study was undertaken to elucidate the effect of Linum usitatissimum fixed oil on experimental esophagitis in albino rats.

METHODS

Group of rats (n = 6), treated with vehicle control (0.9% NaCl, 3 mL/kg, i.p.) or L. usitatissimum fixed oil (1, 2, 3 mL/kg, i.p.) or omeprazole (30 mg/kg, i.p.). Rats were subjected to pylorus and forestomach ligation to induce esophagitis and were compared to a control sham group. Animals were sacrificed after 6 h and evaluated for the gastric pH, gastric volume, total acidity and esophagitis index. Esophageal tissues were further subjected to estimations of sialic acid, collagen, thiobarbituric acid reactive substances, tissue glutathione, catalase and superoxide dismutase.

RESULTS

Treatment with fixed oil significantly inhibited the gastric secretion, total acidity and esophagitis index. The oil also altered the levels of sialic acid and collagen towards normal with significant antioxidant activity in esophageal tissues.

CONCLUSION

The lipoxygenase inhibitory, histamine antagonistic, antisecretory (anticholinergic) and antioxidant activity of the oil was attributed for its effect in reflux esophagitis.

摘要

引言

本研究旨在阐明亚麻籽油对白化病大鼠实验性食管炎的影响。

方法

将大鼠分为几组（n = 6），分别用赋形剂对照（0.9%氯化钠，3 mL/kg，腹腔注射）、亚麻籽油（1、2、3 mL/kg，腹腔注射）或奥美拉唑（30 mg/kg，腹腔注射）处理。通过幽门和前胃结扎诱导大鼠患食管炎，并与假手术对照组进行比较。6小时后处死动物，评估胃pH值、胃容积、总酸度和食管炎指数。进一步对食管组织进行唾液酸、胶原蛋白、硫代巴比妥酸反应物质、组织谷胱甘肽、过氧化氢酶和超氧化物歧化酶的测定。