Snycerski A
Department of Analytical Chemistry, Institute for Drug Research and Control, Warsaw, Poland.
J Pharm Biomed Anal. 1989;7(12):1513-8. doi: 10.1016/0731-7085(89)80159-1.
The polarographic reduction of flutamide was investigated by direct current polarography (DCP), alternating current polarography (ACP), normal pulse polarography (NPP) and differential pulse polarography (DPP). The supporting solution was phosphate buffer containing 5% of 95% ethanol. The reduction process at the dropping mercury electrode was diffusion controlled and irreversible. Extraction with 95% ethanol followed by polarographic reduction was selected as the basis of a method for the determination of flutamide as a pure compound and in tablets.
通过直流极谱法（DCP）、交流极谱法（ACP）、常规脉冲极谱法（NPP）和微分脉冲极谱法（DPP）研究了氟他胺的极谱还原。支持溶液为含有5% 95%乙醇的磷酸盐缓冲液。在滴汞电极上的还原过程受扩散控制且不可逆。选择用95%乙醇萃取后进行极谱还原作为测定纯品氟他胺及其片剂的方法基础。
