Teare F W, Yadav R N, Spino M
J Pharm Sci. 1978 Nov;67(11):1641-2. doi: 10.1002/jps.2600671140.
A differential pulse polarographic assay was developed for determining flucytosine in tablets. The drug is extracted from the sample with water and hydrochloric acid and, after the pH is adjusted, an aliquot is added to the cell and the solution is polarographed at the dropping mercury electrode versus the saturated calomel electrode with 0.066 M Sørensen phosphate buffer (pH 5.6) as the supporting electrolyte. The polarographic peak height enables precise quantitative determination. The Ep value for flucytosine is--1.54 v versus the saturated calomel electrode. The mean recovery of the drug is 101.5% +/- 1.9 (SD). The method is simple, rapid, and precise.
已开发出一种差分脉冲极谱分析法，用于测定片剂中的氟胞嘧啶。该药物用水和盐酸从样品中提取，调节pH值后，取一份样品加入电解池中，并在滴汞电极与饱和甘汞电极之间进行极谱分析，以0.066 M索伦森磷酸盐缓冲液（pH 5.6）作为支持电解质。极谱峰高可实现精确的定量测定。相对于饱和甘汞电极，氟胞嘧啶的Ep值为-1.54 V。该药物的平均回收率为101.5%±1.9（标准差）。该方法简便、快速且精确。
