School of Chemistry, ‡School of Cancer Sciences, College of Medical and Dental Sciences, §School of Biosciences, College of Life and Environmental Sciences, and ∥School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham , Edgbaston, Birmingham, B15 2TT, U.K.
J Med Chem. 2014 Jul 10;57(13):5817-22. doi: 10.1021/jm500246h. Epub 2014 Jun 20.
Examples of organometallic compounds as nucleoside analogues are rare within the field of medicinal bioorganometallic chemistry. We report on the synthesis and properties of two chiral ferrocene derivatives containing a nucleobase and a hydroxyalkyl group. These so-called ferronucleosides show promising anticancer activity, with cytostatic studies on five different cancer cell lines indicating that both functional groups are required for optimal activity.
在医学生物有机金属化学领域，作为核苷类似物的金属有机化合物的例子很少。我们报告了两种含有碱基和羟烷基的手性二茂铁衍生物的合成和性质。这些所谓的 ferronucleosides 表现出有希望的抗癌活性，对五种不同癌细胞系的细胞抑制研究表明，这两个功能基团都是最佳活性所必需的。
