Pinzauti S, Bambagiotti-Alberti M, Moneti G, La Porta E, Coran S A, Vincieri F F, Gratteri P
Dipartimento di Scienze Farmaceutiche, Università di Firenze, Italy.
J Pharm Biomed Anal. 1989;7(12):1611-6. doi: 10.1016/0731-7085(89)80172-4.
Under positive-ion fast atom bombardment (FAB) mass spectrometric conditions, benzalkonium chloride (BAK) afforded intense peaks at m/z 304 and 332, corresponding to the intact cations [M--Cl]+ of C12 and C14 homologues, respectively. The use of benzethonium chloride as an internal standard and thioglycerol as a FAB matrix allowed the direct and specific determination of the BAK content (0.004-0.020%) in commercial hard contact lens solutions through the individual assay of the two alkyl homologues. A linear relationship between the homologue concentration and the peak-area ratio was observed over the concentration range 3-180 micrograms ml-1.
在正离子快原子轰击（FAB）质谱条件下，苯扎氯铵（BAK）在m/z 304和332处产生强峰，分别对应于C12和C14同系物的完整阳离子[M - Cl]+。使用苄索氯铵作为内标，硫代甘油作为FAB基质，通过对两种烷基同系物的单独测定，可以直接、特异性地测定市售硬性隐形眼镜溶液中的BAK含量（0.004 - 0.020%）。在3 - 180微克/毫升的浓度范围内，观察到同系物浓度与峰面积比之间呈线性关系。
