Institute for Molecular Medicine, Stem Cell and Aging, Ulm University, Ulm, Germany; Aging Research Center, Ulm University, Ulm, Germany; Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center and University of Cincinnati, Cincinnati, OH, USA.
AGAPLESION Bethesda Clinic, Geriatric Center Ulm University, Ulm, Germany.
Curr Opin Immunol. 2014 Aug;29:86-92. doi: 10.1016/j.coi.2014.05.002. Epub 2014 Jun 3.
Aging is organized in a hierarchy, in which aging of cells results in aged tissues, ultimately limiting lifespan. For organ systems that also in the adult depend on stem cells for tissue homeostasis like the hematopoietic system that forms immune cells, it is believed that aging of the stem cells strongly contributes to aging-associated dysfunction. In this review, we summarize current aspects on cellular and molecular mechanisms that are associated with aging of hematopoietic stem cells, the role of the stem cell niche for stem cell aging as well as novel and encouraging experimental approaches to attenuate aging of hematopoietic stem cells to target immunosenescence.
衰老是有组织的，细胞衰老导致组织衰老，最终限制了寿命。对于像造血系统这样的在成人期也依赖干细胞来维持组织内稳态的器官系统，人们认为干细胞的衰老强烈促成了与衰老相关的功能障碍。在这篇综述中，我们总结了与造血干细胞衰老相关的细胞和分子机制的最新方面，包括干细胞龛在干细胞衰老中的作用，以及减轻造血干细胞衰老以靶向免疫衰老的新的和令人鼓舞的实验方法。
