Howard Hughes Medical Institute, Department of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Howard Hughes Medical Institute, Department of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Cell. 2014 Jun 5;157(6):1249-1250. doi: 10.1016/j.cell.2014.05.025.
Subcutaneous white adipose tissue can be induced to undergo "browning" and acquire thermogenic capacity in response to physiological stimuli such as cold exposure or exercise. In this issue of Cell, Qiu et al. and Rao et al. demonstrate that pink-staining eosinophils and alternatively activated macrophages play key roles in an immune cascade mediating this metabolic switch.
皮下白色脂肪组织可以在生理刺激（如暴露于寒冷或运动）下发生“褐变”并获得产热能力。在本期《Cell》杂志上，Qiu 等人和 Rao 等人证明，染色呈粉红色的嗜酸性粒细胞和选择性激活的巨噬细胞在介导这种代谢转变的免疫级联反应中发挥关键作用。
