Sapetschnig Alexandra, Miska Eric A
Wellcome Trust/Cancer Research Gurdon Institute, Department of Biochemistry and Department of Genetics, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK.
Wellcome Trust/Cancer Research Gurdon Institute, Department of Biochemistry and Department of Genetics, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK.
Cell. 2014 Jun 5;157(6):1253-1254. doi: 10.1016/j.cell.2014.05.022.
The generation of piRNAs from long primary transcripts requires specialized factors that distinguish these precursors from canonical RNA polymerase II transcripts. Mohn et al. and Zhang et al. provide evidence that in Drosophila melanogaster noncanonical transcription coupled with splicing inhibition differentiates piRNA precursors from mRNAs and ensures their correct processing.
从长链初级转录本生成piRNA需要特定因子，以将这些前体与经典的RNA聚合酶II转录本区分开来。莫恩等人和张等人提供的证据表明，在黑腹果蝇中，非经典转录与剪接抑制相结合，可将piRNA前体与mRNA区分开来，并确保其正确加工。
