微管乙酰化的缓慢之舞。
A slow dance for microtubule acetylation.
机构信息
Department of Chemistry, Dartmouth College, Hanover, NH 03755, USA.
Department of Biological Sciences, Dartmouth College, Hanover, NH 03755, USA.
出版信息
Cell. 2014 Jun 5;157(6):1255-1256. doi: 10.1016/j.cell.2014.05.021.
PMID:24906144
Abstract
Microtubules contribute to diverse cellular processes through balancing dynamic, short-lived and stable, long-lived populations. One way in which long-lived microtubules are marked is by posttranslational acetylation of α-tubulin by tubulin acetyltransferase (TAT). Szyk et al. now provide insight into TAT's mechanism of action and its unique time-stamping ability.
摘要
微管通过平衡动态的、短寿命的和稳定的、长寿命的群体来促进多种细胞过程。长寿命微管被标记的一种方式是通过微管乙酰转移酶（TAT）对α-微管蛋白的翻译后乙酰化。Szyk 等人现在提供了对 TAT 的作用机制及其独特的时间标记能力的深入了解。
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