Erken Haydar Ali, Erken Gülten, Simşek Hasan, Korkut Oğuzhan, Koç Emine Rabia, Yavuz Ozlem, Genç Osman
Department of Physiology, Faculty of Medicine, Balikesir University, Balikesir, Turkey,
Neurol Sci. 2014 Nov;35(11):1807-12. doi: 10.1007/s10072-014-1845-y. Epub 2014 Jun 7.
Varenicline is a new drug for smoking cessation, and its effect on epilepsy is not clear. The aim of this study was to investigate whether different doses of varenicline cause epileptic activity. Forty rats were randomly assigned to the following eight groups: control, saline, and 0.025, 0.04, 0.1, 0.5, 1, and 2 mg kg(-1) varenicline (single dose, i.p.). EEGs were recorded before the varenicline injection and during the following 240 min. While epileptic discharges were observed on the EEGs of the rats in all of the varenicline-treated groups, motor findings of epileptic seizure were not observed in some rats in these groups except the 1 and 2 mg kg(-1) groups. These findings indicate that different single doses of varenicline cause epileptic activity in rats.
伐尼克兰是一种用于戒烟的新药，其对癫痫的影响尚不清楚。本研究的目的是调查不同剂量的伐尼克兰是否会引发癫痫活动。40只大鼠被随机分为以下八组：对照组、生理盐水组以及0.025、0.04、0.1、0.5、1和2 mg·kg⁻¹伐尼克兰组（单次腹腔注射）。在注射伐尼克兰前及随后的240分钟内记录脑电图。虽然在所有接受伐尼克兰治疗的大鼠组的脑电图上均观察到癫痫放电，但除1和2 mg·kg⁻¹组外，这些组中的一些大鼠未观察到癫痫发作的运动表现。这些结果表明，不同单剂量的伐尼克兰会在大鼠中引发癫痫活动。
