Sharma Abhishek, Thakar Saurabh, Lavie Carl J, Garg Jalaj, Krishnamoorthy Parasuram, Sochor Ondrej, Arbab-Zadeh Armin, Lichstein Edgar
Division of Cardiovascular Medicine, State University of New York Downstate Medical Center, Brooklyn, NY, USA,
Curr Cardiol Rep. 2015 Jan;17(1):554. doi: 10.1007/s11886-014-0554-8.
Smoking continues to be the leading cause of preventable deaths in the USA, accounting for one in every five deaths every year, and cardiovascular (CV) disease remains the leading cause of those deaths. Hence, there is increasing awareness to quit smoking among the public and counseling plays an important role in smoking cessation. There are different pharmacological methods to help quit smoking that includes nicotine replacement products available over the counter, including patch, gum, and lozenges, to prescription medications, such as bupropion and varenicline. There have been reports of both nonserious and serious adverse CV events associated with the use of these different pharmacological methods, especially varenicline, which has been gaining media attention recently. Therefore, we systematically reviewed the various pharmacotherapies used in smoking cessation and analyzed the evidence behind these CV events reported with these therapeutic agents.
吸烟仍是美国可预防死亡的首要原因，每年每五例死亡中就有一例与之相关，而心血管疾病仍是这些死亡的主要原因。因此，公众对戒烟的意识日益增强，咨询在戒烟过程中发挥着重要作用。有多种帮助戒烟的药物方法，包括非处方的尼古丁替代产品，如贴片、口香糖和含片，以及处方药，如安非他酮和伐尼克兰。有报道称，使用这些不同的药物方法会出现非严重和严重的不良心血管事件，尤其是伐尼克兰，最近它一直受到媒体关注。因此，我们系统回顾了用于戒烟的各种药物疗法，并分析了这些治疗药物所报告的这些心血管事件背后的证据。
