伐尼克兰作为戒烟最有效药物的肾毒性作用：一项初步实验研究。
Nephrotoxic effects of varenicline as the most effective drug used for smoking cessation: a preliminary experimental study.
作者信息
Koç Akif, Erken Haydar Ali, Koçak Fatma Emel, Yay Arzu, Güçlü Aydin, Sari Erhan, Şimşek Hasan, Önder Gözde Özge, Genç Osman
机构信息
Department of Urology, Faculty of Medicine, Balikesir University, ÇağişYerleşkesi, 10145, Balikesir, Turkey,
出版信息
Int Urol Nephrol. 2015 May;47(5):823-9. doi: 10.1007/s11255-015-0949-5. Epub 2015 Mar 27.
PURPOSE
Varenicline is a new most effective drug for smoking cessation. Its effect on kidney functions remains unclear. This study purposed to investigate whether varenicline causes nephrotoxicity in rats.
METHODS
Fifteen rats were randomly assigned to three groups: control, 0.0125 mg kg(-1) varenicline and 0.025 mg kg(-1) varenicline (single dose for 3 days, i.p.). Before and after experimental period, serum neutrophil gelatinase-associated lipocalin, creatinine and urea levels were measured. Total oxidant and antioxidant status were measured in kidney homogenates. Histological examination was performed in kidney.
RESULTS
The nephrotoxic effects of varenicline were detected by histopathological and biochemical examinations in the varenicline treatment groups. No change was observed in the control group.
CONCLUSIONS
These findings firstly indicate that a 3-day varenicline treatment causes nephrotoxic effects in rats.
目的
伐尼克兰是一种新型的戒烟最有效药物。其对肾功能的影响尚不清楚。本研究旨在调查伐尼克兰是否会在大鼠中引起肾毒性。
方法
将15只大鼠随机分为三组：对照组、0.0125 mg kg(-1)伐尼克兰组和0.025 mg kg(-1)伐尼克兰组（单次给药3天，腹腔注射）。在实验期前后，测量血清中性粒细胞明胶酶相关脂质运载蛋白、肌酐和尿素水平。在肾匀浆中测量总氧化剂和抗氧化剂状态。对肾脏进行组织学检查。
结果
在伐尼克兰治疗组中，通过组织病理学和生化检查检测到伐尼克兰的肾毒性作用。对照组未观察到变化。
结论
这些发现首先表明，为期3天的伐尼克兰治疗会在大鼠中引起肾毒性作用。
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