Departamento de Física Aplicada, Universidad Autónoma de Madrid, 28049, Madrid, Spain.
Departamento de Física Aplicada, Universidad Autónoma de Madrid, 28049, Madrid, Spain.
Carbohydr Polym. 2014 Sep 22;110:238-52. doi: 10.1016/j.carbpol.2014.04.002. Epub 2014 Apr 13.
One of the main applications of porous silicon (PSi) in biomedicine is drug release, either as a single material or as a part of a composite. PSi composites are attractive candidates for drug delivery systems because they can display new chemical and physical characteristics, which are not exhibited by the individual constituents alone. Since cyclodextrin-based polymers have been proven efficient materials for drug delivery, in this work β-cyclodextrin-citric acid in-situ polymerization was used to functionalize two kinds of PSi (nanoporous and macroporous). The synthesized composites were characterized by microscopy techniques (SEM and AFM), physicochemical methods (ATR-FTIR, XPS, water contact angle, TGA and TBO titration) and a preliminary biological assay was performed. Both systems were tested as drug delivery platforms with two different model drugs, namely, ciprofloxacin (an antibiotic) and prednisolone (an anti-inflammatory), in two different media: pure water and PBS solution. Results show that both kinds of PSi/β-cyclodextrin-citric acid polymer composites, nano- and macro-, provide enhanced release control for drug delivery applications than non-functionalized PSi samples.
多孔硅（PSi）在生物医药中的主要应用之一是药物释放，无论是作为单一材料还是作为复合材料的一部分。PSi 复合材料是药物输送系统的有吸引力的候选物，因为它们可以显示出新的化学和物理特性，而这些特性是单个成分所不具备的。由于基于环糊精的聚合物已被证明是有效的药物输送材料，因此在这项工作中，β-环糊精-柠檬酸原位聚合被用于功能化两种 PSi（纳米多孔和大孔）。通过显微镜技术（SEM 和 AFM）、物理化学方法（ATR-FTIR、XPS、水接触角、TGA 和 TBO 滴定）和初步的生物学测定对合成的复合材料进行了表征。两种系统都被测试为药物输送平台，用两种不同的模型药物，即环丙沙星（一种抗生素）和泼尼松龙（一种抗炎药），在两种不同的介质中：纯水和 PBS 溶液。结果表明，与非功能化 PSi 样品相比，纳米和大孔的两种 PSi/β-环糊精-柠檬酸聚合物复合材料都为药物输送应用提供了增强的释放控制。
