Department of Pharmaceutics, YSPM's Yashoda Technical Campus, Wadhephata, Satara, 415011, Maharashtra, India.
Department of Pharmaceutics, Gourishankar Institute of Pharmaceutical Education and Research, Limb, Satara, Maharashtra, India.
Carbohydr Polym. 2017 May 15;164:339-348. doi: 10.1016/j.carbpol.2017.02.005. Epub 2017 Feb 3.
Citric acid crosslinked β-cyclodextrin-carboxymethylcellulose (βCD-CMC) hydrogel films were prepared by esterification-crosslinking method for the controlled release of ketoconazole (model drug). The hydrogel films were evaluated for active βCD content, carboxyl content, swelling ratio, drug loading and release, and hemolytic activity. The structural characterization was carried out using solid state C NMR, ATR-FTIR, TGA and DSC analysis. The βCD-CMC hydrogel films showed increase in active βCD content swelling ratio and drug loading with increase in the concentration of βCD in the feed. The βCD helped to minimize the burst effect and retarded the release of ketoconazole. The hydrogel films were found to be biocompatible and capable of controlling the release of ketoconazole for long duration.
柠檬酸交联的β-环糊精-羧甲基纤维素（βCD-CMC）水凝胶薄膜通过酯化交联法制备，用于控制酮康唑（模型药物）的释放。对水凝胶薄膜的活性βCD 含量、羧基含量、溶胀比、载药量和释放以及溶血活性进行了评估。使用固态 C NMR、ATR-FTIR、TGA 和 DSC 分析进行了结构表征。随着进料中βCD 浓度的增加，βCD-CMC 水凝胶薄膜的活性βCD 含量、溶胀比和载药量均增加。βCD 有助于最小化突释效应并延缓酮康唑的释放。水凝胶薄膜被发现具有生物相容性，并能够长时间控制酮康唑的释放。
