肿瘤厚度作为舌体T1N0和T2N0期鳞状细胞癌淋巴结转移和疾病复发的预测因素。
Tumor thickness as a predictive factor of lymph node metastasis and disease recurrence in T1N0 and T2N0 squamous cell carcinoma of the oral tongue.
作者信息
Matos Leandro Luongo de, Manfro Gabriel, Santos Ricardo Vieira dos, Stabenow Elaine, Mello Evandro Sobroza de, Alves Venâncio Avancini F, Pinto Fábio Roberto, Kulcsar Marco Aurélio Vamondes, Brandão Lenine Garcia, Cernea Cláudio Roberto
机构信息
Head and Neck Surgery Department, University of São Paulo (USP) Medical School, São Paulo, São Paulo, Brazil.
Head and Neck Surgery Department, University of São Paulo (USP) Medical School, São Paulo, São Paulo, Brazil.
出版信息
Oral Surg Oral Med Oral Pathol Oral Radiol. 2014 Aug;118(2):209-17. doi: 10.1016/j.oooo.2014.03.023. Epub 2014 Apr 12.
OBJECTIVE
The aim of the study was to compare the thickness of primary tumors with the frequency of nodal metastases and survival in patients surgically treated for T1/T2N0 oral tongue squamous cell carcinoma.
STUDY DESIGN
This is a retrospective longitudinal study with 74 patients.
RESULTS
None of the patients with a tumor thickness (TT) ≤ 7 mm presented with nodal metastasis, whereas 25 of the patients with a TT > 7 mm (51.0%) developed metastases (P < .0001). Multivariate analysis showed that TT > 7 mm was a risk factor for occult nodal metastasis (odds ratio = 8.7; P = .002) with 81.9% accuracy. TT > 10 mm was also a predictive factor of worse disease-free survival in these patients (hazard ratio = 12.2; P = .003).
CONCLUSIONS
Tumor thickness of greater than 7 mm is predictive of a higher incidence of lymph node metastasis, and a TT > 10 mm is predictive of worse disease-free survival in squamous cell carcinoma of the oral tongue.
目的
本研究旨在比较接受手术治疗的T1/T2N0期口腔舌鳞状细胞癌患者的原发肿瘤厚度与淋巴结转移频率及生存率。
研究设计
这是一项针对74例患者的回顾性纵向研究。
结果
肿瘤厚度（TT）≤7 mm的患者均未出现淋巴结转移，而TT>7 mm的患者中有25例（51.0%）发生了转移（P<.0001）。多因素分析显示，TT>7 mm是隐匿性淋巴结转移的危险因素（比值比=8.7；P=.002），准确率为81.9%。TT>10 mm也是这些患者无病生存期较差的预测因素（风险比=12.2；P=.003）。
结论
肿瘤厚度大于7 mm预示着淋巴结转移发生率较高，而TT>10 mm预示着口腔舌鳞状细胞癌患者的无病生存期较差。
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