Bianchini F, Di Vita A, Palermo L, Piccardi L, Blundo C, Guariglia C
Psychology Department, Sapienza University, Rome, Italy Neuropsychology Unit, IRCCS Santa Lucia Foundation, Rome, Italy
Neuropsychology Unit, IRCCS Santa Lucia Foundation, Rome, Italy.
Am J Alzheimers Dis Other Demen. 2014 Dec;29(8):749-54. doi: 10.1177/1533317514536597. Epub 2014 Jun 5.
The aim of this study was to determine whether an egocentric topographical working memory (WM) deficit is present in the early stages of Alzheimer's disease (AD) with respect to other forms of visuospatial WM. Further, we would investigate whether this deficit could be present in patients having AD without topographical disorientation (TD) signs in everyday life assessed through an informal interview to caregivers. Seven patients with AD and 20 healthy participants performed the Walking Corsi Test and the Corsi Block-Tapping Test. The former test requires memorizing a sequence of places by following a path and the latter is a well-known visuospatial memory task. Patients with AD also performed a verbal WM test to exclude the presence of general WM impairments. Preliminary results suggest that egocentric topographical WM is selectively impaired, with respect to visuospatial and verbal WM, even without TD suggesting an important role of this memory in the early stages of AD.
本研究的目的是确定在阿尔茨海默病（AD）早期相对于其他形式的视觉空间工作记忆（WM）是否存在以自我为中心的地形工作记忆缺陷。此外，我们将调查在通过对照顾者的非正式访谈评估的日常生活中没有地形定向障碍（TD）体征的AD患者中是否存在这种缺陷。7名AD患者和20名健康参与者进行了步行科西测试和科西方块敲击测试。前一项测试要求沿着一条路径记住一系列地点，而后一项是一项著名的视觉空间记忆任务。AD患者还进行了言语工作记忆测试，以排除存在一般工作记忆损害的情况。初步结果表明，即使没有TD，相对于视觉空间和言语工作记忆，以自我为中心的地形工作记忆也有选择性地受损，这表明这种记忆在AD早期起着重要作用。
