Tascilar Koray, Melikoglu Melike, Ugurlu Serdal, Sut Necdet, Caglar Erkan, Yazici Hasan
Department of Rheumatology, Istanbul University Cerrahpasa Medical Faculty, Istanbul and Department of Biostatistics and Medical Informatics, Trakya University Medical Faculty, Edirne, Turkey.
Rheumatology (Oxford). 2014 Nov;53(11):2018-22. doi: 10.1093/rheumatology/keu233. Epub 2014 Jun 6.
Some features of Behçet's syndrome (BS) tend to go together. We aimed to explore the association and timing of various vascular events in both the venous and the arterial vascular tree.
We conducted a chart survey on the type and time of vascular involvement of BS. The cross-relationships of involvement were assessed by phi correlation coefficients. Multiple correspondence analysis was used to identify patterns of vascular involvement. The risk of vascular recurrence was also estimated.
We identified 882 patients with vascular involvement among 5970 BS patients (14.7%). Deep vein thrombosis (DVT), almost always in the legs, was the most frequent single vascular event (592/882; 67.1%). The cumulative risk of a recurrent vascular event was 38.4% at 5 years. Patients with extrapulmonary artery involvement (EPAI) were significantly older than those with venous and pulmonary artery involvement (PAI). There were significant correlations between dural sinus thrombosis (DST) and PAI, Budd-Chiari syndrome (BCS) and inferior vena cava syndrome (IVCS) and between IVCS and superior vena cava syndrome (SVCS). Multiple correspondence analysis further indicated clustering of PAI, DST, BCS, IVCS and SVCS. However, EPAI and DVT clustered separately from forms of vascular disease, the separate clustering of the DVT being attributed to its propensity to occur solo.
The most common type of vascular involvement in BS is solo DVT, almost always occurring in the legs. Various forms of venous disease in BS segregate together and PAI is included in this group. EPAI segregates separately.
白塞病（BS）的一些特征往往同时出现。我们旨在探讨静脉和动脉血管系统中各种血管事件之间的关联及发生时间。
我们对白塞病血管受累的类型和时间进行了图表调查。通过φ相关系数评估受累情况的交叉关系。采用多重对应分析来识别血管受累模式。还估计了血管复发的风险。
我们在5970例白塞病患者中确定了882例有血管受累（14.7%）。深静脉血栓形成（DVT）几乎总是发生在腿部，是最常见的单一血管事件（592/882；67.1%）。5年时血管事件复发的累积风险为38.4%。肺外动脉受累（EPAI）的患者明显比静脉和肺动脉受累（PAI）的患者年龄大。硬脑膜窦血栓形成（DST）与PAI、布加综合征（BCS）与下腔静脉综合征（IVCS）以及IVCS与上腔静脉综合征（SVCS）之间存在显著相关性。多重对应分析进一步表明PAI、DST、BCS、IVCS和SVCS聚集在一起。然而，EPAI和DVT与血管疾病的形式分别聚集，DVT单独聚集归因于其单独发生的倾向。
白塞病最常见的血管受累类型是单独的DVT，几乎总是发生在腿部。白塞病的各种静脉疾病形式聚集在一起，PAI也包括在这一组中。EPAI单独聚集。
