肾移植受者的急性丙型肝炎感染：肝脏还是肾脏优先？
Acute hepatitis C infection in a renal transplant recipient: primacy of the liver or kidney?
作者信息
Althaf Mohammed Mahdi, Abdelsalam Mohamed Said, Rashwan Mohamed, Nadri Quaid
机构信息
Department of Medicine, Section of Nephrology, King Faisal Specialist Hospital and Research Center, Riyadh, Ar-Riyadh, Saudi Arabia.
Department of Medicine, Section of Nephrology, King Faisal Specialist Hospital and Research Center, Riyadh, Ar-Riyadh, Saudi Arabia Internal Medicine Department, Alexandria University, Faculty of Medicine, Alexandria, Egypt.
出版信息
BMJ Case Rep. 2014 Jun 6;2014:bcr2014203643. doi: 10.1136/bcr-2014-203643.
Abstract
We present a case where a renal transplant recipient contracted chronic hepatitis C virus (HCV) infection post-transplantation. The disease progressed and deteriorated leading to fibrosing cholestatic hepatitis that mandated treatment. Treatment with pegylated interferon α-2a and ribavirin was successful in salvaging the liver and eradicating the virus but as a consequence lead to treatment-resistant acute rejection and loss of the renal allograft.
摘要
我们报告了一例肾移植受者在移植后感染慢性丙型肝炎病毒（HCV）的病例。疾病进展并恶化，导致纤维性胆汁淤积性肝炎，需要进行治疗。聚乙二醇化干扰素α-2a和利巴韦林治疗成功挽救了肝脏并清除了病毒，但结果导致了治疗抵抗性急性排斥反应和肾移植受者丧失。
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