边缘叶脑炎中的电压门控钾通道抗体

Voltage-gated potassium channel antibodies in limbic encephalitis.

作者信息

Pozo-Rosich Patricia, Clover Linda, Saiz Albert, Vincent Angela, Graus Francesc

机构信息

Neurosciences Group, Weatherall Insitute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom.

出版信息

Ann Neurol. 2003 Oct;54(4):530-3. doi: 10.1002/ana.10713.

DOI:10.1002/ana.10713

PMID:14520669

Abstract

We found voltage-gated potassium channel (VGKC) antibodies in 4 of 15 patients with limbic encephalitis (LE). Two patients with idiopathic LE had high VGKC antibody levels (>800 pM; controls <100 pM), that fell in parallel with a clinical response to immunotherapy. Two patients with lower VGKC antibodies (170 pM, 300 pM) had lung cancer (radiological evidence only in one) and the LE improved with immunotherapy in one. The other 11 patients without VGKC antibodies had paraneoplastic LE and eight onconeural antibodies (Hu in 6; Ma2 in 2). VGKC antibodies do not unambiguously discriminate between idiopathic or paraneoplastic LE but probably indicate a good response to immunotherapy.

摘要

我们在15例边缘性脑炎（LE）患者中的4例发现了电压门控钾通道（VGKC）抗体。2例特发性LE患者的VGKC抗体水平较高（>800 pM；对照组<100 pM），其抗体水平随免疫治疗的临床反应而平行下降。2例VGKC抗体水平较低（170 pM、300 pM）的患者患有肺癌（仅1例有影像学证据），其中1例患者的LE经免疫治疗后有所改善。其他11例无VGKC抗体的患者患有副肿瘤性LE，并有8种肿瘤相关性抗体（6例为Hu；2例为Ma2）。VGKC抗体并不能明确区分特发性或副肿瘤性LE，但可能提示对免疫治疗有良好反应。