Kalinowski Felicity C, Brown Rikki A M, Ganda Clarissa, Giles Keith M, Epis Michael R, Horsham Jessica, Leedman Peter J
Laboratory for Cancer Medicine, Harry Perkins Institute of Medical Research and University of Western Australia Centre for Medical Research, Perth, WA 6000, Australia.
Department of Dermatology, New York University School of Medicine, New York, NY 10016, USA.
Int J Biochem Cell Biol. 2014 Sep;54:312-7. doi: 10.1016/j.biocel.2014.05.040. Epub 2014 Jun 5.
microRNAs are a family of endogenous, short, non-coding RNAs that play critical roles in regulating gene expression for key cellular processes in normal and abnormal physiology. microRNA-7 is a 23 nucleotide miRNA whose expression is tightly regulated and restricted predominantly to the brain, spleen and pancreas. Reduced levels of miR-7 have been linked to the development of cancer and metastasis. As a tumor suppressor, miR-7 functions to co-ordinately downregulate a number of direct (e.g. the epidermal growth factor receptor) and indirect (e.g. phospho-Akt) growth promoting targets to decrease tumor growth in vitro and in vivo. In addition, miR-7 can increase the sensitivity of treatment-resistant cancer cells to therapeutics and inhibit metastasis. These data suggest that replacement of miR-7 ('miRNA replacement therapy') for specific human cancers could represent a new treatment approach. This article is part of a Directed Issue entitled: The Non-coding RNA Revolution.
微小RNA是一类内源性的、短的非编码RNA，在正常和异常生理学中对关键细胞过程的基因表达调控中发挥着关键作用。微小RNA-7是一种由23个核苷酸组成的微小RNA，其表达受到严格调控，主要局限于脑、脾和胰腺。微小RNA-7水平降低与癌症的发生和转移有关。作为一种肿瘤抑制因子，微小RNA-7通过协同下调许多直接（如表皮生长因子受体）和间接（如磷酸化Akt）促进生长的靶点，在体外和体内减少肿瘤生长。此外，微小RNA-7可增加耐药癌细胞对治疗的敏感性并抑制转移。这些数据表明，针对特定人类癌症的微小RNA-7替代疗法（“微小RNA替代疗法”）可能代表一种新的治疗方法。本文是名为：非编码RNA革命的定向特刊的一部分。
