Schneider Jaime L, Cuervo Ana Maria
Department of Developmental and Molecular Biology, Institute for Aging Studies, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA.
Department of Developmental and Molecular Biology, Institute for Aging Studies, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA.
Curr Opin Genet Dev. 2014 Jun;26:16-23. doi: 10.1016/j.gde.2014.04.003. Epub 2014 Jun 5.
Malfunction of autophagy, the process that mediates breakdown and recycling of intracellular components in lysosomes, has been linked to a variety of human diseases. As the number of pathologies associated with defective autophagy increases, emphasis has switched from the mere description of the status of autophagy in these conditions to a more mechanistic dissection of the autophagic changes. Understanding the reasons behind the autophagic defect, the immediate consequences of the autophagic compromise and how autophagy changes with the evolution of the disease has become a 'must,' especially now that manipulation of autophagy is being considered as a therapeutic strategy. Here, we comment on some of the common themes that have emerged from such detailed analyses of the interplay between autophagy and disease conditions.
自噬是介导细胞内成分在溶酶体中分解和再循环的过程，其功能失调与多种人类疾病有关。随着与自噬缺陷相关的病理状况数量的增加，重点已从仅仅描述这些情况下的自噬状态转向对自噬变化进行更具机制性的剖析。了解自噬缺陷背后的原因、自噬受损的直接后果以及自噬如何随疾病进展而变化已成为“必需”，尤其是现在自噬调控正被视为一种治疗策略。在此，我们对自噬与疾病状况之间相互作用的详细分析中出现的一些共同主题进行评论。
