Chatterjee P K, Jain C L, Sethi P D
Central Indian Pharmacopoeia Laboratory, Ghaziabad.
J Pharm Biomed Anal. 1989;7(6):693-8. doi: 10.1016/0731-7085(89)80113-x.
Two spectrophotometric methods have been developed for the simultaneous determination of chlorzoxazone and acetaminophen in their combined dosage forms. No preliminary separation step is required in either method. The first, an absorbance ratio technique using the isoabsorptive point as one of the wavelengths, together with "Q curve" analysis gives accurate and reproducible results for both drugs. The second, a difference spectrophotometric method is based on measurement of absorbance of an alkaline solution relative to that of an acidic solution of identical concentration of the sample at two different wavelengths. The method is suitable for routine analysis of such combinations of the drugs.
已开发出两种分光光度法，用于同时测定氯唑沙宗和对乙酰氨基酚复方制剂中的这两种成分。两种方法均无需初步分离步骤。第一种是吸光度比技术，使用等吸收点作为波长之一，并结合“Q曲线”分析，可对两种药物给出准确且可重复的结果。第二种是差示分光光度法，基于在两个不同波长下测量样品相同浓度的碱性溶液相对于酸性溶液的吸光度。该方法适用于此类药物组合的常规分析。
