College of Materials Science & Engineering, Changzhou University, Changzhou 213164, Jiangsu, PR China.
College of Materials Science & Engineering, Changzhou University, Changzhou 213164, Jiangsu, PR China.
Mater Sci Eng C Mater Biol Appl. 2014 Aug 1;41:1-7. doi: 10.1016/j.msec.2014.04.031. Epub 2014 Apr 18.
The hydrophobic inert surface of poly(ethylene terephthalate) (PET) film has limited its practical bioapplications, in which case, better biocompatibility should be achieved by surface modification. In this work, the copolymer of functional β-cyclodextrin derivatives and styrene grafted surfaces was prepared via surface-initiated atom transfer radical polymerization (SI-ATRP) on initiator-immobilized PET. The structures, composition, properties, and surface morphology of the modified PET films were characterized by fourier transform infrared spectroscopy (FTIR), X-ray photoelectron spectroscopy (XPS), contact angle measurement, and scanning electronic microscopy (SEM). The results show that the surface of PET films was covered by a thick targeted copolymer layer, and the hydrophobic surface of PET was changed into an amphiphilic surface. The copolymer-grafted surfaces were also shown good biocompatibility on which SGC-7901 A549 and A549/DDP cells readily attached and proliferated, demonstrating that the functional copolymer-grafted PET films could be a promising alternative to biomaterials especially for tissue engineering.
聚对苯二甲酸乙二醇酯（PET）薄膜的疏水性惰性表面限制了其实际的生物应用，在这种情况下，通过表面改性可以获得更好的生物相容性。在这项工作中，通过在引发剂固定化 PET 上的表面引发原子转移自由基聚合（SI-ATRP），制备了功能β-环糊精衍生物和苯乙烯接枝表面的共聚物。通过傅里叶变换红外光谱（FTIR）、X 射线光电子能谱（XPS）、接触角测量和扫描电子显微镜（SEM）对改性 PET 薄膜的结构、组成、性能和表面形貌进行了表征。结果表明，PET 薄膜的表面被一层厚厚的目标共聚物层覆盖，PET 的疏水性表面变成了两性表面。接枝共聚物的表面也表现出良好的生物相容性，SGC-7901、A549 和 A549/DDP 细胞易于附着和增殖，表明功能共聚物接枝 PET 薄膜可能是生物材料的一种有前途的替代品，特别是在组织工程方面。
