Thapa Rupendra, Lakhey Mamta, Yadav Pradeep Kumar
Department of Pathology, Kathmandu Medical College, Sinamangal, Kathmandu, Medicare National Hospital & Research Centre, Chabahil, Kathmandu, Nepal.
Medicare National Hospital & Research Centre, Chabahil, Kathmandu, Nepal.
JNMA J Nepal Med Assoc. 2013 Jul-Sep;52(191):449-52.
Colorectal carcinoma (CRC) ranks as the fourth most frequent cancer in men (after lung, prostate and stomach cancer), and third in women (after cancers of breast and uterine cervix).Adenocarcinoma of the colon is the most common malignancy of the GI tract and is a major cause of morbidity and mortality worldwide. It is also one of the most common cancers in Nepal.
A descriptive study was conducted in a Kathmandu based Hospital. This study included 50 cases of colorectal carcinoma diagnosed on colonoscopic/sigmoidoscopic biopsies over a period of two years.
A total of 50 patients were studied out of these, 29 (58%) patients were male, whereas 21 (42%) were with male:female ratio of 1.3:1. Age ranged was from 20 years to 80 years. Maximum number of cases were observed between the ages of 61-70 years. The most common histological type of colorectal carcinoma was moderately differentiated adenocarcinoma and seen in 37(74%) cases. Left sided tumor constituted 40 (80%) cases of all tumors and rectum was the predominant site with 26 (52%) cases followed by sigmoid colon with 7 (14%) cases.
Colorectal carcinoma (CRC) is not an uncommon disease in this part of the world. The use of sigmoidoscopy and colonoscopy along with biopsy when required should be encouraged as a screening program for colorectal carcinoma in an elderly age group for the detection of CRC at an earlier stage.
结直肠癌（CRC）在男性中是第四大常见癌症（仅次于肺癌、前列腺癌和胃癌），在女性中是第三大常见癌症（仅次于乳腺癌和宫颈癌）。结肠癌腺癌是胃肠道最常见的恶性肿瘤，是全球发病和死亡的主要原因。它也是尼泊尔最常见的癌症之一。
在加德满都的一家医院进行了一项描述性研究。本研究纳入了在两年期间经结肠镜/乙状结肠镜活检确诊的50例结直肠癌病例。
共研究了50例患者，其中29例（58%）为男性，21例（42%）为女性，男女比例为1.3:1。年龄范围为20岁至80岁。61 - 70岁年龄段观察到的病例数最多。结直肠癌最常见的组织学类型是中分化腺癌，见于37例（74%）。左侧肿瘤占所有肿瘤的40例（80%），直肠是主要部位，有26例（52%），其次是乙状结肠，有7例（14%）。
在世界这一地区，结直肠癌（CRC）并非罕见疾病。应鼓励在老年人群中使用乙状结肠镜检查和结肠镜检查，并在必要时进行活检，作为结直肠癌的筛查项目，以便在早期发现CRC。
