Ali Hassam, Ishtiaq Rizwan, Tedder Brandon, Zweigle Joshua, Nomigolzar Romina, Dahiya Dushyant S, Moond Vishali, Humza Sohail Amir, Patel Pratik, Basuli Debargha, Tillmann Hans L
Department of Gastroenterology, Hepatology & Nutrition ECU Health Medical Center, Brody School of Medicine Greenville North Carolina USA.
Department of Internal Medicine University of Connecticut Health Center Farmington Connecticut USA.
JGH Open. 2024 Apr 15;8(4):e13064. doi: 10.1002/jgh3.13064. eCollection 2024 Apr.
This study investigates temporal trends in gastrointestinal cancer-related mortality in the United States between 1999 and 2020, focusing on differences by sex, age, and race.
We investigated the Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research multiple causes of death database (Years 1999-2020) for gastrointestinal cancer-related mortality with a focus on the underlying cause of death.
A total of 3 115 243 gastrointestinal cancer-related deaths occurred from 1999 to 2020. The overall age-adjusted mortality rate decreased from 46.7 per 100 000 in 1999 to 38.4 per 100 000 in 2020. The average annual percent change (AAPC) for the study period was -0.9% (95% CI: -1.0%, -0.9%, < 0.001), with no significant difference in AAPC between the sexes but some difference between races and related to individual cancers. African Americans and Asian Americans, and Pacific Islanders experienced a greater decrease in mortality compared with Whites. Mortality rates for American Indian and Alaskan Native populations also decreased significantly from 1999 to 2020 ( < 0.001). There were significant declines in esophageal, stomach, colon, rectal, and gallbladder cancer-related mortality but increases in the small bowel, anal, pancreatic, and hepatic cancer-related mortality ( < 0.001), with variation across different sexes and racial groups.
While overall gastrointestinal cancer-related mortality declined significantly in the United States from 1999 to 2020, mortality from some cancers increased. Furthermore, differences between sexes and racial groups underscore crucial differences in gastrointestinal cancer mortality, highlighting areas for future research.
本研究调查了1999年至2020年间美国胃肠道癌相关死亡率的时间趋势，重点关注性别、年龄和种族差异。
我们研究了疾病控制与预防中心的广泛在线流行病学研究多死因数据库（1999 - 2020年）中与胃肠道癌相关的死亡率，重点关注根本死因。
1999年至2020年间，共有3115243例与胃肠道癌相关的死亡。总体年龄调整死亡率从1999年的每10万人46.7例降至2020年的每10万人38.4例。研究期间的平均年变化百分比（AAPC）为-0.9%（95%CI：-1.0%，-0.9%，<0.001），两性之间的AAPC无显著差异，但种族之间以及与个别癌症有关的方面存在一些差异。与白人相比，非裔美国人和亚裔及太平洋岛民的死亡率下降幅度更大。1999年至2020年期间，美国印第安人和阿拉斯加原住民的死亡率也显著下降（<0.001）。食管癌、胃癌、结肠癌、直肠癌和胆囊癌相关死亡率显著下降，但小肠癌、肛门癌、胰腺癌和肝癌相关死亡率上升（<0.001），不同性别和种族群体存在差异。
虽然1999年至2020年间美国胃肠道癌相关总体死亡率显著下降，但某些癌症的死亡率有所上升。此外，性别和种族群体之间的差异凸显了胃肠道癌死亡率的关键差异，为未来研究指明了方向。
