Zhang Hengzhu, Du Renfei, Huang Yu-Hua, She Lei, Dong Lun, Wang Xiaodong, Kwan Aij-Lie
Department of Neurosurgery, Yangzhou Medical College, Yangzhou University, Yangzhou, China.
Department of Neurosurgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.
Clin Neurol Neurosurg. 2014 Jul;122:120-3. doi: 10.1016/j.clineuro.2014.04.028. Epub 2014 May 6.
Pituitary tumor transforming gene (PTTG) is an oncogene and has been detected in several tumors of unrelated histological origin. However, its role in meningiomas is unknown so far. We aim to investigate PTTG expression in intracranial meningiomas, and clarify the relationship between PTTG and the histopathological types of tumors.
Over a 7-year period, 195 meningioma specimens were collected from 195 patients. Seventeen nonneoplastic meningeal tissues were used as controls. We analyze PTTG expression by tissue microarray with immunohistochemistry.
Immunoexpression of PTTG was identified in 172 of 195 meningiomas, accounting for 88.2%. All of immunoexpression of tumors were found to be cytoplasmic, and no nuclear expression was observed. In the control group, there were 3 of 17 specimens (17.6%) with positive PTTG expression. The percentage of high expression WHO subtypes of meningiomas ranged from 0% to 95.7%. We further stratified the tumors into 3 subgroups based on pathological grading (WHO grade I, WHO grade II and III, control), and there was significant intergroup difference in PTTG expression (p<0.001).
This study demonstrated that PTTG was expressed in most of meningioma tissues, and the degree of PTTG immunostaining was variable in the subtypes of tumors. Further investigations into PTTG expression are required to broaden the pathogenesis research of meningiomas.
垂体瘤转化基因（PTTG）是一种癌基因，已在多种组织学来源不相关的肿瘤中被检测到。然而，其在脑膜瘤中的作用至今仍不清楚。我们旨在研究PTTG在颅内脑膜瘤中的表达情况，并阐明PTTG与肿瘤组织病理学类型之间的关系。
在7年的时间里，从195例患者中收集了195份脑膜瘤标本。17份非肿瘤性脑膜组织用作对照。我们通过组织芯片免疫组化分析PTTG的表达。
195例脑膜瘤中有172例检测到PTTG免疫表达，占88.2%。所有肿瘤的免疫表达均位于细胞质中，未观察到细胞核表达。在对照组中，17份标本中有3份（17.6%）PTTG表达呈阳性。脑膜瘤WHO高表达亚型的比例在0%至95.7%之间。我们根据病理分级（WHO I级、WHO II级和III级、对照组）将肿瘤进一步分为3个亚组，PTTG表达在组间存在显著差异（p<0.001）。
本研究表明，PTTG在大多数脑膜瘤组织中表达，且在肿瘤亚型中PTTG免疫染色程度各不相同。需要对PTTG表达进行进一步研究，以拓宽脑膜瘤发病机制的研究。
