Salahadeen E, Torp-Pedersen C, Gislason G, Hansen P R, Ahlehoff O
Department of Cardiology, Copenhagen University Hospital Gentofte, Hellerup, Denmark.
J Eur Acad Dermatol Venereol. 2015 May;29(5):1002-5. doi: 10.1111/jdv.12523. Epub 2014 Jun 9.
Psoriasis is a common chronic disease, mediated by type 1 and 17 helper T cell-driven inflammation. Epidemiological studies have demonstrated a wide range of comorbidities and increased mortality rates. However, the current evidence on psoriasis-related mortality is limited and nationwide data have not been presented previously.
In a nationwide population-based cohort we evaluated all-cause and cause-specific death rates in patients with psoriasis as compared to the general population.
The entire Danish population aged 18 and above, corresponding to a total of 5,458,627 individuals (50.7% female, 40.9 years ± 19.7), including 94,069 with mild psoriasis (53% female, 42.0 ± 17.0 years) and 28,253 with severe psoriasis (53.4% female, 43.0 ± 16.5 years), was included. A total of 884,661 deaths were recorded, including 10 916 in patients with mild psoriasis and 3699 in patients with severe psoriasis. The age at time of death varied by psoriasis status, i.e. 76.5 ± 14.0, 74.4 ± 12.8 and 72.0 ± 13.4 years, for the general population, mild psoriasis and severe psoriasis respectively. In general, the highest death rates were observed in patients with severe psoriasis. Overall death rates per 1000 patient years were 13.8 [confidence interval (CI) 13.8-13.8], 17.0 (CI 16.7-17.3) and 25.4 (CI 24.6-26.3) for the general population, patients with mild psoriasis and patients with severe psoriasis respectively.
This nationwide population-based study of cause-specific death rates in patients with psoriasis demonstrated reduced lifespan and increased rates of all examined specific causes of death in patients with psoriasis compared to the general population.
银屑病是一种常见的慢性疾病，由1型和17型辅助性T细胞驱动炎症介导。流行病学研究已证实其存在广泛的合并症及死亡率增加的情况。然而，目前关于银屑病相关死亡率的证据有限，且此前尚未有全国性数据公布。
在一项基于全国人群的队列研究中，我们评估了银屑病患者与普通人群相比的全因死亡率和特定病因死亡率。
纳入了丹麦所有18岁及以上的人群，共计5,458,627人（女性占50.7%，年龄40.9岁±19.7岁），其中包括94,069例轻度银屑病患者（女性占53%，年龄42.0±17.0岁）和28,253例重度银屑病患者（女性占53.4%，年龄43.0±16.5岁）。共记录了884,661例死亡病例，其中轻度银屑病患者中有10916例死亡，重度银屑病患者中有3699例死亡。死亡时的年龄因银屑病病情而异，普通人群、轻度银屑病患者和重度银屑病患者分别为76.5±14.0岁、74.4±12.8岁和72.0±13.4岁。总体而言，重度银屑病患者的死亡率最高。普通人群、轻度银屑病患者和重度银屑病患者每1000患者年的总体死亡率分别为13.8[置信区间（CI）13.8 - 13.8]、17.0（CI 16.7 - 17.3）和25.4（CI 24.6 - 26.3）。
这项基于全国人群的银屑病患者特定病因死亡率研究表明，与普通人群相比，银屑病患者的寿命缩短，所有检查的特定死因死亡率增加。
