Department of Cardiology, Copenhagen University Hospital - Herlev and Gentofte, Copenhagen, Denmark.
Department of Dermatology and Allergy, Copenhagen University Hospital - Herlev and Gentofte, Copenhagen, Denmark.
Sci Rep. 2021 Nov 2;11(1):21438. doi: 10.1038/s41598-021-00999-9.
Psoriasis is linked with increased risk of cardiovascular disease (CVD) that is underestimated by traditional risk stratification. We conducted a large-scale plasma proteomic analysis by use of a proximity extension assay in 85 patients with a history of moderate-to-severe psoriasis with or without established atherosclerotic CVD. Differentially expressed proteins associated with CVD were correlated with subclinical atherosclerotic markers including vascular inflammation determined by F-fluorodeoxyglucose positron emission tomography/computed tomography, carotid intima-media thickness (CIMT), carotid artery plaques, and coronary artery calcium score (CCS) in the patients without CVD and statin treatment. We also examined the association between the neutrophil-to-lymphocyte ratio (NLR) and subclinical atherosclerosis. In unadjusted analyses, growth differentiation factor-15 (GDF-15) levels and NLR were increased, while tumor necrosis factor (TNF)-related activation-inducing ligand (TRANCE) and TNF-related apoptosis-induced ligand (TRAIL) levels were decreased in patients with established CVD compared to those without CVD. Among patients with psoriasis without CVD and statin treatment, GDF-15 levels were negatively associated with vascular inflammation in the ascending aorta and entire aorta, and positively associated with CIMT and CCS. NLR was positively associated with vascular inflammation in the carotid arteries. Our data suggest that circulating GDF-15 levels and NLR might serve as biomarkers of subclinical atherosclerosis in patients with psoriasis.
银屑病与心血管疾病（CVD）风险增加有关，而传统的风险分层方法低估了这种风险。我们通过使用邻近延伸分析对 85 名有中重度银屑病病史的患者进行了大规模的血浆蛋白质组学分析，这些患者中有或没有已确诊的动脉粥样硬化性 CVD。与 CVD 相关的差异表达蛋白与亚临床动脉粥样硬化标志物相关，包括通过 F-氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描（F-FDG PET/CT）确定的血管炎症、颈动脉内膜中层厚度（CIMT）、颈动脉斑块和冠状动脉钙评分（CCS）在无 CVD 和他汀类药物治疗的患者中。我们还检查了中性粒细胞与淋巴细胞比值（NLR）与亚临床动脉粥样硬化之间的关系。在未调整的分析中，与无 CVD 的患者相比，患有已确诊 CVD 的患者的生长分化因子 15（GDF-15）水平和 NLR 升高，而肿瘤坏死因子（TNF）相关激活诱导配体（TRANCE）和 TNF 相关凋亡诱导配体（TRAIL）水平降低。在无 CVD 和他汀类药物治疗的银屑病患者中，GDF-15 水平与升主动脉和整个主动脉的血管炎症呈负相关，与 CIMT 和 CCS 呈正相关。NLR 与颈动脉的血管炎症呈正相关。我们的数据表明，循环 GDF-15 水平和 NLR 可能是银屑病患者亚临床动脉粥样硬化的生物标志物。
