Liu Jian, Wan Lei, Liu Lei, Cheng Yuanyuan, Feng Yunxia, Huang Chuanbing, Wang Yuan
First Affiliated Hospital, Anhui University of Chinese Medicine, Hefei 230031, China.
Anhui University of Chinese Medicine, Hefei 230038, China.
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2014 Jun;30(6):639-42.
To investigate the relationships between B, T lymphocyte attenuator (BTLA), regulatory T (Treg) cells and reduced lung function of patients with rheumatism.
The lung function of 482 patients of rheumatism, including rheumatoid arthritis (RA, 198 cases), ankylosing spondylitis (AS, 114 cases), Sjogren's syndrome (SS, 102 cases) and osteoarthritis (OA, 68 cases), were detected by spirometer. BTLA and Treg cells of peripheral blood in 482 patients with rheumatic diseases were observed using flow cytometry.
Lung function and the expressions of BTLA and Treg cells were lower in patients with rheumatism than those in normal controls. Lung function parameters, such as forced expiratory volume in 1 second (FEV1), peak expiratory flow (PEF), forced expiratory flow at 50% of forced vital capacity (FEF50), forced expiratory flow at 75% of forced vital capacity (FEF75), were higher in the rheumatism group with normal BTLA and Treg cells than those in the group with abnormal BTLA and Treg cells (P<0.05 or P<0.01). Correlation analysis showed that there were positive correlations between lung function parameters orced vital capacity(FVC), maximal voluntary ventilation (MVV), FEV1, forced expiratory flow at 25% of forced vital capacity (FEF25), FEF50 and BTLA, Tregs. There were negative correlations between lung function parameters FVC, FEV1, FEF50, FEF75 and IL-4, IgA, IgM (P<0.05 or P<0.01).
The decline in lung function of patients with rheumatism is related to down-regulation of BTLA, Tregs and excessively abnormal activation of T and B cells.
探讨B、T淋巴细胞衰减器（BTLA）、调节性T（Treg）细胞与风湿性疾病患者肺功能降低之间的关系。
采用肺功能仪检测482例风湿性疾病患者的肺功能，其中包括类风湿关节炎（RA，198例）、强直性脊柱炎（AS，114例）、干燥综合征（SS，102例）和骨关节炎（OA，68例）。采用流式细胞术观察482例风湿性疾病患者外周血中的BTLA和Treg细胞。
风湿性疾病患者的肺功能以及BTLA和Treg细胞的表达低于正常对照组。BTLA和Treg细胞正常的风湿性疾病组的肺功能参数，如1秒用力呼气容积（FEV1）、呼气峰值流速（PEF）、用力肺活量50%时的用力呼气流量（FEF50）、用力肺活量75%时的用力呼气流量（FEF75），高于BTLA和Treg细胞异常的组（P<0.05或P<0.01）。相关性分析显示，肺功能参数用力肺活量（FVC）、最大自主通气量（MVV）、FEV1、用力肺活量25%时的用力呼气流量（FEF25）、FEF50与BTLA、Tregs之间存在正相关。肺功能参数FVC、FEV1、FEF50、FEF75与IL-4、IgA、IgM之间存在负相关（P<0.05或P<0.01）。
风湿性疾病患者肺功能下降与BTLA、Tregs下调以及T和B细胞过度异常激活有关。
