Medical Oncology 1 Unit, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy.
AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Service de Neurologie 2, Paris 75013, France; National Neurological Institute C. Mondino, University of Pavia, Italy.
Cancer Treat Rev. 2014 Sep;40(8):951-9. doi: 10.1016/j.ctrv.2014.05.007. Epub 2014 May 27.
The frequency of metastatic brain tumors has increased over recent years; the primary tumors most involved are breast cancer, lung cancer, melanoma and renal cell carcinoma. While radiation therapy and surgery remain the mainstay treatment in selected patients, new molecular drugs have been developed for brain metastases. Studies so far report interesting results. This review focuses on systemic cytotoxic drugs and, in particular, on new targeted therapies and their clinically relevant activities in brain metastases from solid tumors in adults.
近年来，转移性脑肿瘤的发病率有所增加；最常涉及的原发性肿瘤有乳腺癌、肺癌、黑色素瘤和肾细胞癌。虽然放射治疗和手术仍然是某些患者的主要治疗方法，但新的分子药物已被开发用于脑转移瘤。迄今为止的研究报告了有趣的结果。这篇综述重点介绍了全身细胞毒性药物，特别是新的靶向治疗及其在成人实体瘤脑转移中的临床相关活性。
