Dipartimento di Chimica, Università degli Studi di Parma and INSTM Udr Parma, Parco Area delle Scienze 17A, 43124 Parma (Italy).
Angew Chem Int Ed Engl. 2014 Aug 25;53(35):9183-8. doi: 10.1002/anie.201404774. Epub 2014 Jun 6.
The direct, clean, and unbiased transduction of molecular recognition into a readable and reproducible response is the biggest challenge associated to the use of synthetic receptors in sensing. All possible solutions demand the mastering of molecular recognition at the solid-liquid interface as prerequisite. The socially relevant issue of screening amine-based illicit and designer drugs is addressed by nanomechanical recognition at the silicon-water interface. The methylamino moieties of different drugs are all first recognized by a single cavitand receptor through a synergistic set of weak interactions. The peculiar recognition ability of the cavitand is then transferred with high fidelity and robustness on silicon microcantilevers and harnessed to realize a nanomechanical device for label-free detection of these drugs in water.
将分子识别直接、清晰且无偏地转化为可读且可重复的响应，是与合成受体在传感中应用相关的最大挑战。所有可能的解决方案都需要掌握固-液界面处的分子识别，作为前提条件。硅-水界面上的纳米机械识别解决了基于胺的非法和设计药物筛选这一与社会息息相关的问题。不同药物的甲氨基部分首先通过一组协同的弱相互作用被单个主体识别。然后，主体的特殊识别能力以高保真度和鲁棒性转移到硅微悬臂梁上，并利用其实现用于在水中无标记检测这些药物的纳米机械装置。
