白细胞介素-23受体基因多态性rs2201841与银屑病关节炎相关。
IL-23R gene polymorphism rs2201841 is associated with psoriatic arthritis.
作者信息
Popadic S, Ramic Z, Medenica Lj, Pravica V, Popadic D
机构信息
Department of Dermatovenereology, School of Medicine, University of Belgrade, Belgrade, Serbia; Clinic of Dermatovenereology, Clinical Center of Serbia, Belgrade, Serbia.
出版信息
Int J Immunogenet. 2014 Aug;41(4):335-7. doi: 10.1111/iji.12127. Epub 2014 Jun 9.
We examined rs2201841 within IL-23R gene in Serbian patients with psoriasis and healthy controls. G allele frequency was significantly increased in the group of patients with psoriatic arthritis compared with controls (0.481 vs 0.308). Carriage of G allele increases risk to develop psoriatic arthritis (P = 0.009, OR = 3.311, 95% CI 1.29-8.70).
我们在塞尔维亚银屑病患者和健康对照者中检测了白细胞介素23受体（IL-23R）基因中的rs2201841。与对照组相比，银屑病关节炎患者组中的G等位基因频率显著升高（0.481对0.308）。携带G等位基因会增加患银屑病关节炎的风险（P = 0.009，比值比[OR]= 3.311，95%置信区间[CI]为1.29 - 8.70）。
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