在接触两种碳氯烃的小鼠中表现出不同的行为效应剂量反应谱：结构和物理性质的影响。
Different behavioral effect dose-response profiles in mice exposed to two-carbon chlorinated hydrocarbons: influence of structural and physical properties.
机构信息
Center for Environmental Measurement and Analysis, National Institute for Environmental Studies, Tsukuba, Ibaraki 305-8506, Japan.
出版信息
Toxicol Appl Pharmacol. 2014 Sep 1;279(2):103-12. doi: 10.1016/j.taap.2014.05.012. Epub 2014 Jun 6.
The present study aimed to clarify whether dose-response profiles of acute behavioral effects of 1,2-dichloroethane (DCE), 1,1,1-trichloroethane (TCE), trichloroethylene (TRIC), and tetrachloroethylene (PERC) differ. A test battery involving 6 behavioral endpoints was applied to evaluate the effects of DCE, TCE, TRIC, and PERC in male ICR strain mice under the same experimental conditions. The behavioral effect dose-response profiles of these compounds differed. Regression analysis was used to evaluate the relationship between the dose-response profiles and structural and physical properties of the compounds. Dose-response profile differences correlated significantly with differences in specific structural and physical properties. These results suggest that differences in specific structural and physical properties of DCE, TCE, TRIC, and PERC are responsible for differences in behavioral effects that lead to a variety of dose-response profiles.
本研究旨在阐明 1,2-二氯乙烷（DCE）、1,1,1-三氯乙烷（TCE）、三氯乙烯（TRIC）和四氯乙烯（PERC）急性行为效应的剂量-反应曲线是否存在差异。在相同的实验条件下，采用包含 6 个行为终点的测试组合，评估 DCE、TCE、TRIC 和 PERC 对雄性 ICR 品系小鼠的影响。这些化合物的行为效应剂量-反应曲线存在差异。回归分析用于评估这些化合物的剂量-反应曲线与结构和物理性质之间的关系。剂量-反应曲线差异与化合物的特定结构和物理性质差异显著相关。这些结果表明，DCE、TCE、TRIC 和 PERC 的特定结构和物理性质的差异是导致行为效应差异的原因，进而导致各种剂量-反应曲线的差异。
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