Tyczyno Malgorzata, Halota Waldemar, Nowak Wojciech, Pawlowska Małgorzata
Department of Infectious Diseases and Hepatology, Nicolaus Copernicus University, Bydgoszcz, Poland.
Hepat Mon. 2014 May 3;14(5):e14559. doi: 10.5812/hepatmon.14559. eCollection 2014 May.
According to many studies, one of the social groups with high rate of HCV infections are prisoners.
The aim of the study was to determine and compare the genotypes distribution among prisoners and patients of hospital.
HCV genotypes among prisoners (281 inmates) and patients of hospital (1415 patients) were determined in years 2002-2012. HCV genotypes were determined in 2002-2005 with INNO-LiPA HCV II test (Innogenetics, Gent, Belgium) and since 2006 with LINEAR ARRAY assay (Roche, Mannheim, Germany), after isolation and amplification of the material with COBAS AMPLICOR v 2.0 (Roche, Mannheim, Germany).
The most frequent HCV genotype among inmates was genotype 3, which was detected in169 of 281 patients (60.1%). Most frequent genotype among hospitalized was genotype 1, which was found in 1127 cases (79.6%). Comparing the results of prisoners with a group of patients with HIV/HCV co-infection gave similar results. In both groups most frequent was genotype 3 (respectively 60.1 and 45.5%). However, most prisoners in this study (96%) were HIV-negative.
The current study shows that the predominant HCV genotype among inmates from prison in Potulice is genotype 3.
根据多项研究，丙型肝炎病毒（HCV）感染率较高的社会群体之一是囚犯。
本研究的目的是确定并比较囚犯和医院患者中HCV基因型的分布情况。
在2002年至2012年期间确定了囚犯（281名囚犯）和医院患者（1415名患者）中的HCV基因型。2002年至2005年使用INNO-LiPA HCV II检测法（比利时根特的Innogenetics公司）确定HCV基因型，自2006年起使用线性阵列分析（德国曼海姆的罗氏公司），材料经COBAS AMPLICOR v 2.0（德国曼海姆的罗氏公司）分离和扩增后进行检测。
囚犯中最常见的HCV基因型是3型，在281名患者中的169名（60.1%）中检测到。住院患者中最常见的基因型是1型，在1127例（79.6%）中发现。将囚犯的结果与一组HIV/HCV合并感染患者的结果进行比较，得到了相似的结果。两组中最常见的都是3型（分别为60.1%和45.5%）。然而，本研究中的大多数囚犯（96%）HIV呈阴性。
当前研究表明，波图利采监狱囚犯中主要的HCV基因型是3型。
