多奈哌齐可逆转尼古丁戒断诱导的C57BL/6J小鼠情境恐惧条件反射缺陷。
Donepezil reverses nicotine withdrawal-induced deficits in contextual fear conditioning in C57BL/6J mice.
作者信息
Poole Rachel L, Connor David A, Gould Thomas J
机构信息
Department of Psychology Neuroscience Program, Temple University.
出版信息
Behav Neurosci. 2014 Oct;128(5):588-93. doi: 10.1037/bne0000003. Epub 2014 Jun 9.
Abstract
Withdrawal from chronic nicotine is associated with cognitive deficits. Therapies that ameliorate cognitive deficits during withdrawal aid in preventing relapse during quit attempts. Withdrawal-induced deficits in contextual learning are associated with nicotinic acetylcholine receptor upregulation. The aim of the present study was to determine if the acetylcholinesterase inhibitor donepezil has the ability to reverse nicotine withdrawal-induced deficits in contextual learning. Results demonstrated that low doses of donepezil, which do not enhance contextual learning or alter locomotor activity/anxiety-related behavior, can reverse nicotine withdrawal-induced deficits in contextual learning. Thus, donepezil may have therapeutic value for ameliorating cognitive deficits associated with nicotine withdrawal and for preventing relapse.
摘要
长期尼古丁戒断与认知缺陷有关。在戒断期间改善认知缺陷的疗法有助于防止戒烟尝试期间的复吸。戒断引起的情境学习缺陷与烟碱型乙酰胆碱受体上调有关。本研究的目的是确定乙酰胆碱酯酶抑制剂多奈哌齐是否有能力逆转尼古丁戒断引起的情境学习缺陷。结果表明，低剂量的多奈哌齐不会增强情境学习或改变运动活动/焦虑相关行为，但可以逆转尼古丁戒断引起的情境学习缺陷。因此，多奈哌齐可能对改善与尼古丁戒断相关的认知缺陷和预防复吸具有治疗价值。
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