Fratila Raluca M, Mitchell Scott G, del Pino Pablo, Grazu Valeria, de la Fuente Jesús M
Instituto de Nanociencia de Aragon (INA), Universidad de Zaragoza , C/Mariano Esquillor s/n, 50018 Zaragoza, Spain.
Langmuir. 2014 Dec 23;30(50):15057-71. doi: 10.1021/la5015658. Epub 2014 Jun 25.
The field of nanotechnology applied to medicine (nanomedicine) is developing at a fast pace and is expected to provide solutions for early diagnosis, targeted therapy, and personalized medicine. However, designing nanomaterials for biomedical applications is not a trivial task. Avoidance of the immune system, stability in physiological media, control over the interaction of a nanomaterial with biological entities such as proteins and cell membranes, low toxicity, and optimal bioperformance are critical for the success of the designed nanomaterial. In this Feature Article we provide a concise overview of some of the most recent advances concerning the derivatization of gold and iron oxide nanoparticles for bioapplications. The most important aspects relating to the functionalization of gold and iron oxide nanoparticles with carbohydrates, peptides, nucleic acids, and antibodies are covered, highlighting the recent contributions from our research group. We suggest tips for the appropriate (bio)functionalization of these inorganic nanoparticles in order to preserve the biological activity of the attached biomolecules and ensure their subsequent stability in physiological media.
应用于医学的纳米技术领域（纳米医学）正在迅速发展，有望为早期诊断、靶向治疗和个性化医疗提供解决方案。然而，设计用于生物医学应用的纳米材料并非易事。避免免疫系统识别、在生理介质中的稳定性、控制纳米材料与蛋白质和细胞膜等生物实体的相互作用、低毒性以及最佳生物性能对于所设计纳米材料的成功至关重要。在这篇专题文章中，我们简要概述了金纳米颗粒和氧化铁纳米颗粒用于生物应用衍生化的一些最新进展。涵盖了与用碳水化合物、肽、核酸和抗体对金纳米颗粒和氧化铁纳米颗粒进行功能化相关的最重要方面，并突出了我们研究小组的最新贡献。我们提出了对这些无机纳米颗粒进行适当（生物）功能化的建议，以保持所连接生物分子的生物活性，并确保它们在生理介质中的后续稳定性。
