Istituto Italiano di Tecnologia, 16163 Genova, Italy.
Pharmacol Res. 2010 Aug;62(2):126-43. doi: 10.1016/j.phrs.2009.12.012. Epub 2010 Jan 4.
In the last decade the progress achieved on the synthesis of inorganic nanostructures has been accompanied by the parallel exploitation of these systems in various fields, among them are biology and medicine. We provide here an overview of the iron-based inorganic nanostructured materials that have been developed and tested in these fields. We will highlight the major concepts on the preparation, physical properties and applications of such nanostructures, starting from the most investigated iron oxide nanoparticles. We will describe then the new generation of inorganic hybrid nanostructures, which are structures that integrate in each nano-object multiple inorganic nanocrystals of different materials. In our discussion we will focus on those works that have provided a sound proof of concept on the potential of the various systems as diagnostic and therapeutic agents.
在过去的十年中，无机纳米结构的合成取得了进展，与此同时，这些系统在各个领域也得到了广泛的应用，其中包括生物学和医学。本文综述了在这些领域中开发和测试的基于铁的无机纳米结构材料。我们将重点介绍这些纳米结构的制备、物理性质和应用的主要概念，从最具研究价值的氧化铁纳米颗粒开始。然后，我们将描述新一代的无机杂化纳米结构，即每个纳米物体中集成了多种不同材料的纳米晶体的结构。在讨论中，我们将重点关注那些为各种系统作为诊断和治疗剂的潜在应用提供了有力证据的工作。
