Pérez Aguilar F, Breto M, del Val A, Berenguer J
An Med Interna. 1989 Mar;6(3):119-24.
27 patients with radiolucent biliary stones in normofunctioning gall bladder were treated with a combination of CDCA and UDCA (CDCA doses = 7.7 mg/kg/day; UDCA--6.5 mg/kg/day); only 23 continued in the study for at least one year. The reasons for leaving were in one case the necessity of a cholecystectomy and treatment interruption in 3 cases. The rate of complete dissolution was of 39%, being of 17% the partial dissolution rate. The only biochemical alteration was the increase of HDL cholesterol at 9 and 12 months of treatment (p less than 0.05 and p less than 0.01 respectively). Transient diarrhea was seen in 17% of the patients and it did not require treatment. The incidence of liver colic during the year before treatment was 26% and it decreased during the 1st year of treatment to 4%. The non-specific dyspepsia observed during the year before treatment was of 48%, and decreased to 17% during the first year of treatment. Only one patient developed calcification of the gallstone, 12 months after treatment.
27例胆囊功能正常但存在透光性胆结石的患者接受了熊去氧胆酸（CDCA）和牛磺熊去氧胆酸（UDCA）联合治疗（CDCA剂量 = 7.7毫克/千克/天；UDCA - 6.5毫克/千克/天）；只有23例患者持续参与研究至少一年。退出的原因，一例是需要进行胆囊切除术，三例是治疗中断。完全溶解率为39%，部分溶解率为17%。唯一的生化改变是治疗9个月和12个月时高密度脂蛋白胆固醇升高（分别为p < 0.05和p < 0.01）。17%的患者出现短暂性腹泻，无需治疗。治疗前一年胆绞痛的发生率为26%，治疗第一年降至4%。治疗前一年观察到的非特异性消化不良发生率为48%，治疗第一年降至17%。仅1例患者在治疗12个月后胆结石出现钙化。
