Polli E E, Bianchi P A, Conte D, Sironi L
Digestion. 1981;22(4):185-91. doi: 10.1159/000198643.
Patients with radiolucent gallstones (diameter less than 1.5 cm) and functioning gallbladder were treated for 6-12 months with CDCA (38 patients, 12-15 mg/kg/day) or UDCA (78 patients randomly allocated to receive 5-6 or 10-12 mg/kg/day). Complete dissolutions and partial plus complete dissolutions were respectively 26 and 58% for CDCA, 14 and 58% for UDCA at the lower dose, and 29 and 71% for UDCA at the higher dose. Statistical analysis did not show any significant difference between the three different treatments. In patients with stones of 4-10 mm diameter treated with UDCA, complete dissolution occurred at the lower dose in 0 of 14 cases while complete dissolutions occurred at the higher dose in 5 of 18 cases, suggesting that the latter dose may be more effective (0.05 less than P less than 0.1). A highly significant correlation was demonstrated between gallstone size and number of dissolutions with both doses of UDCA. No side effects were observed with UDCA, while with CDCA diarrhea occurred in 28% and a transient increase in SGOT in a single patient. 1 patient on UDCA required emergency cholecystectomy for acute cholecystitis. Dyspeptic and/or pain symptom-atology improved in 65 and 85% of the patients treated with CDCA and UDCA, respectively. No variations in the blood lipids were observed.
对胆囊造影显示为透光性结石（直径小于1.5厘米）且胆囊功能正常的患者，使用鹅去氧胆酸（CDCA，38例患者，12 - 15毫克/千克/天）或熊去氧胆酸（UDCA，78例患者随机分配接受5 - 6毫克/千克/天或10 - 12毫克/千克/天）进行6至12个月的治疗。CDCA治疗的完全溶解率和部分加完全溶解率分别为26%和58%；低剂量UDCA治疗的完全溶解率和部分加完全溶解率分别为14%和58%；高剂量UDCA治疗的完全溶解率和部分加完全溶解率分别为29%和71%。统计学分析显示三种不同治疗方法之间无显著差异。在接受UDCA治疗的直径为4 - 10毫米结石的患者中，低剂量组14例患者均未出现完全溶解，而高剂量组18例中有5例出现完全溶解，提示高剂量可能更有效（0.05＜P＜0.1）。两种剂量的UDCA治疗均显示结石大小与溶解次数之间存在高度显著相关性。UDCA未观察到副作用，而CDCA治疗中28%的患者出现腹泻，1例患者血清谷草转氨酶短暂升高。1例接受UDCA治疗的患者因急性胆囊炎需要急诊胆囊切除术。接受CDCA和UDCA治疗的患者中，消化不良和/或疼痛症状分别有65%和85%得到改善。未观察到血脂变化。
