The interplay between hyperglycemia-induced oxidative stress markers and the level of soluble receptor for advanced glycation end products (sRAGE) in K562 cells.

Formation and accumulation of advanced glycation end-products (AGE) and also generation of reactive oxygen species (ROS), the main causative players in the context of diabetes, are intensified under hyperglycemic condition. The consequences from AGE/RAGE interaction could be attenuated by the soluble form of RAGE, termed sRAGE. In the current study, we studied the link between hyperglycemia-induced oxidative stress and the level of soluble form of RAGE in K562 cells. Our data revealed a positive correlation between high glucose and/or AGE-modified albumin treatment and oxidative stress status. Besides, a significant decrease in soluble RAGE level following treatments with either AGE-modified albumin or high glucose was observed. However, pretreatment with an appropriate antioxidant such as Resveratrol, markedly elevated the sRAGE level. Hence, sRAGE therapy could be further evaluated as an effective therapeutical approach to attenuate some of the diabetes complications.