Brockmeyer Fabian, Schoemaker Robin, Schmidtmann Marc, Martens Jürgen
Institut für Chemie, Carl von Ossietzky Universität Oldenburg, P. O. Box 2503, Carl-von-Ossietzky-Str. 9-11, 26111 Oldenburg, Germany.
Org Biomol Chem. 2014 Jul 28;12(28):5168-81. doi: 10.1039/c4ob00866a.
A two-step sequence for the synthesis of various 3,4-dihydro-2H-1,3-thiazines is presented. In the first step, 2H-1,3-thiazines were prepared by a new multicomponent reaction (MCR). Starting from β-chlorovinyl aldehydes, this MCR offers an efficient and facile access to 2,2-dialkyl- and 2-alkyl-2-aralkyl-5,6-diaryl-2H-1,3-thiazines. The potential of these products in subsequent reactions was verified by the conversion to 3,4-dihydro-2H-1,3-thiazine-containing bisamides, β-lactams, and methoxy amides.
本文介绍了一种用于合成各种3,4-二氢-2H-1,3-噻嗪的两步反应序列。第一步，通过一种新的多组分反应（MCR）制备2H-1,3-噻嗪。从β-氯代乙烯醛开始，该MCR为合成2,2-二烷基-和2-烷基-2-芳烷基-5,6-二芳基-2H-1,3-噻嗪提供了一种高效且简便的方法。通过将这些产物转化为含3,4-二氢-2H-1,3-噻嗪的双酰胺、β-内酰胺和甲氧基酰胺，验证了它们在后续反应中的潜力。
