Gimbert Carolina, Vallribera Adelina
Department of Chemistry, Universitat Autonoma de Barcelona, Cerdanyola del Valles, 08193 Barcelona, Spain.
Org Lett. 2009 Jan 15;11(2):269-71. doi: 10.1021/ol802346r.
A series of 4H-3,1-benzothiazines have been successfully synthesized through a three-step sequence starting from commercially available 2-iodoaniline. The key step consists of the cyclization of compounds 6 via an intramolecular S-conjugate addition. The synthesis is straightforward, gives good yields and offers a broad range of possibilities since R can be many alkyl or aryl groups and Z a suitable electron-withdrawing functionalization.
通过从市售的2-碘苯胺开始的三步序列，成功合成了一系列4H-3,1-苯并噻嗪。关键步骤包括化合物6通过分子内S-共轭加成的环化反应。该合成方法简单直接，产率良好，并且由于R可以是许多烷基或芳基，Z可以是合适的吸电子官能团，因此提供了广泛的可能性。
